Willow bark has a long history of traditional use for reducing minor pain. Several randomized human trials illustrate its ability to do so primarily through the actions of salicin, a source of salicylic acid. Additionally, it helps to maintain healthy prostaglandin metabolism and blood flow.
Boswellia serrata has also revealed the potential to provide statistically significant support for reducing mild pain.
AKBA, or 3-acetyl-11-keto-beta-boswellic acid, may be particularly supportive in maintaining healthy 5-lipoxygenase enzyme activity and leukotriene metabolism to maintain tissue comfort.
Curcumin maintains healthy cyclooxygenase-2 enzyme activity while supporting healthy prostaglandin, leukotriene and thromboxane metabolism.
Devils claw promotes both healthy cyclooxygenase-2 and 5-lipoxygenase enzyme activity.
A review of 12 human studies indicates that devils claw may reduce mild pain to promote musculoskeletal comfort and function. dl-Phenylalanine supports enkephalin activity, which impacts pain receptive neurons.*
This formula is designed to reduce occasional, minor pain by supporting healthy enzyme and immune mediator activities.*